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REVIEW ARTICLE Table of Contents   
Year : 2021  |  Volume : 46  |  Issue : 2  |  Page : 191-194
Efficacy of tetravalent dengue vaccine: A systematic review and meta-analysis


1 Department of Community Medicine, Shri Shankaracharya Institute of Medical Sciences, Bhilai, Chhattisgarh, India
2 Department of Community Medicine, Seth G.S. Medical College, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Ashish Wasudeo Khobragade
Department of Community Medicine, Shri Shankaracharya Institute of Medical Sciences, Flat No. C-18, Bhilai, Chhattisgarh - 490 020
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijcm.IJCM_608_20

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Dengue is one of the neglected tropical diseases caused by flavivirus. Live-attenuated tetravalent vaccine is launched for the age group of 9–45 years. It is given in three doses schedule. Eleven studies were included in meta-analysis by following PRISMA guidelines. Healthy persons in the age group of 2–45 years were included in these studies. Statistical analysis was done by “R” software. Pooled relative risk among vaccinated versus control group was calculated using random-effect model. Pooled dengue vaccine efficacy was calculated from relative risk. Heterogeneity and publication bias were assessed using Baujat and funnel plot, respectively. Adverse effects following immunization were reviewed. Pooled vaccine efficacy is 58% (95% confidence interval 46%-67%). I2 statistics is 81.4%.


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  2007 - Indian Journal of Community Medicine | Published by Wolters Kluwer - Medknow
  Online since 15th September, 2007