Indian Journal of Community Medicine

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 35  |  Issue : 1  |  Page : 134--137

Sero-Surveillance to assess immunity to rubella and assessment of immunogenicity and safety of a single dose of rubella vaccine in school girls


Hitt Sharma1, Sunil Chowdhari2, Tilak Raj Raina2, Subodh Bhardwaj3, Gajanan Namjoshi1, Sameer Parekh1 
1 Serum Institute of India Ltd, Pune, India
2 Government Medical College and Associated Hospitals, Jammu, India
3 Earlier with Serum Institute of India Ltd, Pune, India

Correspondence Address:
Hitt Sharma
Serum Institute of India Ltd, 212/2, Off Soli Poonawalla Road, Hadapsar, Pune-411 028
India

Background: Rubella vaccination is not yet included in National Immunization Schedule in India. Serosurvey is frequently used to assess epidemiologic pattern of Rubella in a community. Serosurveys in different parts of India have found that 6-47% of women are susceptible for Rubella infection. The present serosurveillance was conducted in Jammu, India, in two public schools. Objective: To determine serological status of Rubella antibodies of school girls and assessment of immunogenicity and reactogenicity of Rubella immunization in seronegative girls. Materials and Methods: The current study was conducted to determine Rubella serostatus in peripubertal schoolgirls aged 11-18 years and also to assess immunogenicity and safety of Rubella vaccine (R-Vac) of Serum Institute of India Ltd., Pune, in seronegative girls. For screening, pre-vaccination serum Rubella IgG antibodies were determined and to assess immunogenicity of the vaccine, post-vaccination IgG antibodies were compared with pre-vaccination levels. Safety assessment was done for a period of 8 weeks, post-vaccination. Results: A total of 90 (32.7%) seronegative girls were vaccinated. All girls (100%) became seropositive, post-vaccination. Clinically relevant and statistically significant increase in anti-Rubella IgG titres was observed. The adverse events were mild and self-limiting. Conclusions: R-Vac vaccine used in the study demonstrated an excellent safety and immunogenicity profile.


How to cite this article:
Sharma H, Chowdhari S, Raina TR, Bhardwaj S, Namjoshi G, Parekh S. Sero-Surveillance to assess immunity to rubella and assessment of immunogenicity and safety of a single dose of rubella vaccine in school girls.Indian J Community Med 2010;35:134-137


How to cite this URL:
Sharma H, Chowdhari S, Raina TR, Bhardwaj S, Namjoshi G, Parekh S. Sero-Surveillance to assess immunity to rubella and assessment of immunogenicity and safety of a single dose of rubella vaccine in school girls. Indian J Community Med [serial online] 2010 [cited 2020 May 30 ];35:134-137
Available from: http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2010;volume=35;issue=1;spage=134;epage=137;aulast=Sharma;type=0