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 Table of Contents    
ORIGINAL ARTICLE  
Year : 2017  |  Volume : 42  |  Issue : 4  |  Page : 214-217
 

Rapid response to syphilis outbreak among female sex workers


1 Department of Community Medicine, Government Medical College, Surat, Gujarat, India
2 Department of Microbiology, Government Medical College, Surat, Gujarat, India
3 Department of Dermatology, Government Medical College, Surat, Gujarat, India
4 Department of Obstetrics and Gynaecology, Government Medical College, Surat, Gujarat, India

Date of Web Publication25-Oct-2017

Correspondence Address:
J K Kosambiya
Department of Community Medicine, Government Medical College, Surat, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijcm.IJCM_254_16

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   Abstract 

Background: Outbreak of syphilis, i.e., 16 cases of rapid plasma reagin (RPR) reactive cases of syphilis was reported in Community Based Organization (CBO) Sahyog of Surat, India, from April to August 2014. The aim of the study was to find risk factors and take immediate actions to prevent spread. Materials and Methods: Outbreak investigation of 16 Female Sex Workers of CBO Sahyog in Surat who were found Rapid Plasma Reagin (RPR) and Treponema Pallidum Hemagglutination Assay (TPHA) positive from April to August 2014; was carried out. Clinico-epidemiological and laboratory-based evidence for different sexually transmitted infections (STIs) conducted at Government Medical College, New Civil Hospital, Surat. Root cause analysis (RCA) of index case was carried out. Results: Desk review for the past 3 years data of STI revealed total STI cases as 88 (2011), 95 (2012), and 130 (2013), of which 4, 2, and 2 found RPR reactive, respectively. Data from April to August 2014 revealed 16 RPR reactive cases and confirmed by TPHA. On examination, one had ulcerative cervical lesion, rest did not have any symptoms of syphilis. Eleven had vaginal/cervical discharge, 11 had lower abdominal pain. A total of 11 had unprotected sex, 7 encountered condom tear in the past 6 months, and 5 reported sexual violence. Seven had sexual activity under influence of alcohol. Laboratory investigation revealed two as HIV-positive. RPR reactivity reported highest (9 out of 16) from same area of hotspot. RCA of probable index case revealed factors responsible as violence and nonuse of condoms. Conclusions: Outbreak investigation revealed one probable index case. All 16 treated with injection Penidure. Violence or condom tear is responsible for the spread. Crisis management team should be strengthened.


Keywords: Female sex workers, nonuse of condom, rapid plasma reagin reactive, violence, crisis


How to cite this article:
Surti SB, Kosambiya J K, Khokhar N, Patni MM, Gohil AH, Kamdar ZN, Umrigar D, Verma R, Mulla S. Rapid response to syphilis outbreak among female sex workers. Indian J Community Med 2017;42:214-7

How to cite this URL:
Surti SB, Kosambiya J K, Khokhar N, Patni MM, Gohil AH, Kamdar ZN, Umrigar D, Verma R, Mulla S. Rapid response to syphilis outbreak among female sex workers. Indian J Community Med [serial online] 2017 [cited 2020 Jun 5];42:214-7. Available from: http://www.ijcm.org.in/text.asp?2017/42/4/214/217227



   Introduction Top


About 498 million people aged between 15 and 49 years are infected with chlamydia, trichomoniasis, syphilis, and gonorrhea each year. Greater than or equal to 5 percent sex workers are infected with syphilis in 34 countries.[1] In 2012, there were total 40,393 syphilis' cases in India.[2]

Since 2000, Community Based Organization (CBO) Sahyog is implementing TI among female sex workers (FSWs). According to the National AIDS Control Organization (NACO) guidelines, in every 3 months, key population have to undergo routine medical checkups and every 6 months, they are tested for syphilis by screening test, rapid plasma reagin (RPR). If RPR test is reactive, the case is confirmed by Treponema pallidum hemagglutination assay (TPHA) and referred for treatment to New Civil Hospital, Surat (NCHS).

The objectives were:

  1. To document the features of cases of syphilis among FSWs of Surat City, India
  2. To identify the risk factors responsible for the spread of disease and prevent its further spread.



   Materials and Methods Top


The study was conducted during September 2014 at Surat city of Gujarat state. The inclusion criteria for the study were FSWs who were registered at Sahyog CBO and found RPR reactive between April and August 2014. The list of the cases was obtained by desk review of Sahyog data of RPR reactivity of the past 3 years and the cases found positive during the study period were included in this study. Semi-structured predesigned questionnaire was used to interview the patients in the presence of their peer educators. There was no loss to follow-up during the study. All the cases were provided appropriate treatment according to the NACO guidelines.

The main domains covered in the questionnaire were: sociodemographic profile, history of sexually transmitted infection (STI) and HIV/AIDS, current signs-symptoms, use of condom and other contraception, violence during activity, and occurrence of condom tear. The patients were accompanied to Departments of Obstetrics and Gynaecology (O and G) and Skin and Venereal Diseases of NCHS for clinical examination. Special onsite microscopy laboratory at O and G Department was established to avoid loss to follow-up for laboratory specimen collection and investigations with all aseptic precautions. Majority of the tests were done at Microbiology Department, NCHS; for polymerase chain reaction (PCR) for Chlamydia trachomatis and Neisseria gonorrhoeae and fluorescent treponemal antibody absorption (FTA-ABS) test, samples were sent to Apex-Regional STD Teaching, Training and Research Centre at V.M Medical College and Safdarjung Hospital, New Delhi, in cold chain. Index case was identified, and in-depth interview for root cause analysis (RCA) of the probable index case was carried out by doctor trained in qualitative research. The quantitative data were analyzed by percentages and proportions. RCA was analyzed by generating appropriate codes and themes.

The interviews were conducted in separate room at PSM Department of NCH in the presence of their peer educator. Informed written consent for interview and its audio recording was obtained from each patient.


   Results Top


Mean age of the patients was 39 years (standard deviation ± 10.95). Out of 16 patients, 10 (63.0%) were in this profession for more than 10 years, while 4 (25.0%) were for 6–9 years, and 2 (12.0%) for 2–5 years. The study revealed that 62.5% of all the patients were illiterate, 25.0% had attended primary school, and 12.5% had attended secondary school.

Out of 16 patients, 4 (25.0%) were unmarried, 5 (31.2%) were married but currently separated, 3 (18.7%) are currently married, 2 (12.5%) are divorced, 1 (6.2%) was widowed, and 1 (6.2%) is in live-in relationship. The study revealed that out of 16 patients, area of hotspot of 9 patients (56.2%) was Ring Road, stretching from railway station to Majura gate, 4 (25.2%) worked from home, one was from (6.2%) Khajuravadi, and one (6.2%) was from Kosad awas [Table 1] and [Table 2] and [Figure 1] and [Figure 2].
Table 1: Clinical profile of the patients (n=16)

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Table 2: History of unprotected sexual activity, use of condom, and violence faced by the patients

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Figure 1: Epidemic curve depicting trend of syphilis in the year 2014 (rapid plasma reagin reactivity)

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Figure 2: Root cause analysis using fishbone diagram showing various factors responsible for the index case

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   Discussion Top


Syphilis is an ancient disease but remains a major health challenge.[3] The global prevalence rate of syphilis has again surged because of multiple biological and social factors and it has imposed considerable health and economic burden.[4],[5],[6],[7],[8] The syphilis outbreak was confirmed on the basis of desk review, and the present study focused on the factors which could have led to this outbreak. The study reported that nearly 63% of the patients were working in this profession since more than 10 years. Given that syphilis in clients of FSWs is not rare,[9] it is suggested that FSWs with more clients and longer experience of selling sex would be more vulnerable to syphilis.

Majority of patients in the present study were illiterate or had primary school education which makes them vulnerable.[10]

Majority (9 out of 16, 56%) of the patients were working from the area of hotspot that is Ring Road, Surat, so the same network of clients may have served as a bridge of infection among FSWs in such a short period.

Four patients had a history of painless ulcer, whereas others denied history of ulcer ever in their life. Majority (11 out of 16) had complaints of lower abdominal pain followed by (9 out of 16) cervical discharge. All the patients were suffering from latent syphilis as none had active ulcers or rashes on palms and soles or other symptoms of secondary syphilis.

The study reported that two patients had concurrent HIV infection. Prevalence of HIV/AIDS in FSWs in India is 2.8%.[11] The present study confirmed seven patients out of 16 by FTA-ABS to be positive for syphilis. The sensitivity of RPR, FTA-ABS, and TPHA for latent syphilis is 60%–70%, 95%–100%, and 95%–100%, respectively.[12]

Inconsistent condom use with clients has been found in the majority of our patients. Totally, 11 out of 16 confirmed unprotected sex in the past 6 months. However, condoms remain a good strategy to reduce the risk of acquiring or transmitting STIs.[12],[13] Reasons were mainly client negligence or force. FSWs, encountering clients refusing to use condoms, have limited room for negotiation if they want to keep the client's business.[14] Furthermore, inconsistent use with regular partner and husband was observed. These sexual partnerships could then act as bridges between sex workers and the general population.[15]


   Conclusion Top


Outbreak investigation with high suspicion revealed one probable index case. Violence or condom tear was found responsible for the spread. All the cases were latent cases of syphilis. Out of 16 RPR reactive FSWs, 11 (68.7%) had unprotected sexual activity, 7 (43.7%) had reported condom tear, and 5 (31.2%) had reported violence majorly due to forceful group sex. Common associated STI found is candidiasis in 5 (31.2%) and bacterial vaginosis in 4 (25.0%). All 16 were treated with injection Penidure to reduce further spread.

The limitations of the study are that the findings reflect outbreak investigation only. Partner/client notification and treatment were difficult to obtain as the patient did not have any way to contact their casual clients. The strength of the study is very good rapport with Sahyog Mahila Mandal which is formed by PARAS-PSM Project that facilitated referral from field level to tertiary care level facility. Furthermore, the study is strengthened by substantial microbiological and venereological evidence which supports the information collected by the questionnaire and helps describe the outbreak.

Acknowledgment

The authors would like to acknowledge Apex-Regional STD Teaching, Training and Research Centre at V.M Medical College and Safdarjung Hospital, New Delhi for carrying out laboratory investigations for PCR for Chlamydia trachomatis and Neisseria gonorrhoeae and FTA-ABS (Treponema pallidum).

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
   References Top

1.
WHO Organisation, Sexually Transmitted Infections. Global Health Observatory Data, Geneva. Available from: http://www.who.int/gho/sti/en/. [Last accessed on 2014 Sep 14].  Back to cited text no. 1
    
2.
Government of India, Monthly Health Condition Reports from Directorate of Health Services of States/UTs, New Delhi; 2012.  Back to cited text no. 2
    
3.
Hook EW 3rd, Peeling RW. Syphilis control – A continuing challenge. N Engl J Med 2004;351:122-4.  Back to cited text no. 3
    
4.
Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance. Atlanta, USA; 2011-2012.  Back to cited text no. 4
    
5.
Kourbatova EV, Akovbyan VA, Chesson HW, Lytkina IN, Dmitriev GA, Tikhonova LI, et al. Assessment of the routine, occupation-based gonorrhea and syphilis screening program in Moscow, Russia: An analysis of sexually transmitted infection prevalence and cost-effectiveness. Sex Transm Dis 2008;35:453-60.  Back to cited text no. 5
    
6.
Chen XS, Wang QQ, Yin YP, Liang GJ, Jiang N, Yang LG, et al. Prevalence of syphilis infection in different tiers of female sex workers in China: Implications for surveillance and interventions. BMC Infect Dis 2012;12:84.  Back to cited text no. 6
    
7.
Schneider JA, Lakshmi V, Dandona R, Kumar GA, Sudha T, Dandona L. Population-based seroprevalence of HSV-2 and syphilis in Andhra Pradesh state of India. BMC Infect Dis 2010;10:59.  Back to cited text no. 7
    
8.
Chico RM, Mayaud P, Ariti C, Mabey D, Ronsmans C, Chandramohan D. Prevalence of malaria and sexually transmitted and reproductive tract infections in pregnancy in Sub-Saharan Africa: A systematic review. JAMA 2012;307:2079-86.  Back to cited text no. 8
    
9.
Hong FC, Feng TJ, Cai YM, Wen LZ, Pan P, Lan LN, et al. Burden of syphilis infections in Shenzhen, China: A preliminary estimation. Int J STD AIDS 2009;20:115-8.  Back to cited text no. 9
    
10.
Solomon MM, Smith MJ, del Rio C. Low educational level: A risk factor for sexually transmitted infections among commercial sex workers in Quito, Ecuador. Int J STD AIDS 2008;19:264-7.  Back to cited text no. 10
    
11.
National AIDS Control Organization, Ministry of Health and Family Welfare, Government of India. National Behavioural Surveillance Survey (BSS) among Female Sex Workers in India, New Delhi; 2006.  Back to cited text no. 11
    
12.
Ananthanarayan R. Ananthanarayan and Paniker's Textbook of Microbiology. 8th ed. Orient Blackswan; 2009.  Back to cited text no. 12
    
13.
Laga M, Alary M, Nzila N, Manoka AT, Tuliza M, Behets F, et al. Condom promotion, sexually transmitted diseases treatment, and declining incidence of HIV-1 infection in female Zairian sex workers. Lancet 1994;344:246-8.  Back to cited text no. 13
    
14.
Holmes KK, Levine R, Weaver M. Effectiveness of condoms in preventing sexually transmitted infections. Bull World Health Organ 2004;82:454-61.  Back to cited text no. 14
    
15.
Ruan Y, Cao X, Qian HZ, Zhang L, Qin G, Jiang Z, et al. Syphilis among female sex workers in Southwestern China: Potential for HIV transmission. Sex Transm Dis 2006;33:719-23.  Back to cited text no. 15
    


    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1], [Table 2]



 

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